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Index > Protein center > Kng1(Gene name) > Mouse
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  • Kng1 (Gene name),
  • Kininogen-1 (Protein name ),  KNG1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Kng1(Kng);
    Protein name:
    Kininogen-1;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Isoform LMW interacts with CRISP3.
    Function:
    (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    661
    Sequence:
    50:
    MKLITTLLLC | SGLLLTLTQG | EEAQEIDCND | EAVFQAVDFS | LKQFNPGVKS | 
    100:
    GNQYMLHRVI | EGTKTDGSPT | FYSFKYLIKE | GNCSAQSGLA | WQDCDFKDAE | 
    150:
    EAATGECTAT | VGKRENEFFI | VTQTCKIAPS | KAPILKAYFP | CIGCVHAIST | 
    200:
    DSPDLEPVLK | HSIEHFNNNT | DHSHLFTLRK | VKSAHRQVVA | GLNFDITYTI | 
    250:
    VQTNCSKERF | PSLHGDCVAL | PNGDDGECRG | NLFMDINNKI | ANFSQSCTLY | 
    300:
    SGDDLVEALP | KPCPGCPRDI | PVDSPELKEV | LGHSIAQLNA | ENDHPFYYKI | 
    350:
    DTVKKATSQV | VAGTKYVIEF | IARETKCSKE | SNTELAEDCE | IKHLGQSLDC | 
    400:
    NANVYMRPWE | NKVVPTVKCQ | ALDMTEMARR | PPGFSPFRSV | TVQETKEGRT | 
    450:
    VSPPYIAREQ | EERDAETEQG | PTHGHGWLHE | KQIKANKNHR | GHKHGHDHGH | 
    500:
    WSPRRHGLGH | GHQKPHGLGH | GHQLKLDYLR | HQREDGDDHT | HTVGHGHGHG | 
    550:
    HGHGHGHGHG | HGHGHGHGHG | HGHGKHTNKD | KNSVKQTTQR | TESLASSSEY | 
    600:
    STTSTQMQGR | TEGPTLTPPR | AQPTVTSSGF | QDSDFIEDVV | ATTPPYDTGA | 
    650:
    HDDLIPDIHV | QPDSLSFKLI | SDFPEATSPK | CPGRPWKPAS | WEDPNTETTE | 
    661:
    FSDFDLLDAL | S
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Kininogen-1
    Cat.:
    E1805r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Kininogen-1
    Cat.:
    E1805b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Kininogen-1
    Cat.:
    E1805h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    Please sign in first.
    ELISA Kit for Mouse Kininogen-1
    Cat.:
    E1805m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kininogen-1
    Cat.:
    U1805h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Kininogen-1
    Cat.:
    U1805b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kininogen-1
    Cat.:
    U1805r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kininogen-1
    Cat.:
    U1805m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Kininogen-1
    Polyclonal Antibody for Mouse Kininogen-1
    Cat.:
    P1805Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kininogen-1
    Cat.:
    P1805Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kininogen-1
    Cat.:
    P1805Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Kininogen-1
    Monoclonal Antibody for Mouse Kininogen-1
    Monoclonal Antibody for Mouse Kininogen-1
    Monoclonal Antibody for Mouse Kininogen-1
    Protein for Mouse Kininogen-1
    Protein for Mouse Kininogen-1
    Protein for Mouse Kininogen-1
    Protein for Mouse Kininogen-1

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    References
    1. 1.
      "Molecular cloning of cDNAs for mouse low-molecular-weight and high-molecular-weight prekininogens."
      Takano M. , Kondo J. , Yayama K. , Otani M. , Sano K. , Okamoto H.
      Biochim. Biophys. Acta1352:222-230(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HMW AND LMW)
      strain: C57BL/6 X CBA.
      tissue: Liver.
    2. 2.
      "Structure and expression of two kininogen genes in mice."
      Cardoso C.C. , Garrett T. , Cayla C. , Meneton P. , Pesquero J.B. , Bader M.
      Biol. Chem.385:295-301(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      strain: FVB/N.
    3. 3.
      "Characterization of high molecular weight kininogen gene duplication in mice."
      Merkulov S.M. , Komar A.A. , McCrae K.R.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      strain: C57BL/6.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW)
      strain: C57BL/6J.
      tissue: Placenta.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS HMW AND LMW)
      strain: FVB/N.
      tissue: Liver.
    6. 6.
      "Human CRISP-3 binds serum alpha1B-glycoprotein across species."
      Udby L. , Johnsen A.H. , Borregaard N.
      Biochim. Biophys. Acta1800:481-485(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-35 AND 389-403 (ISOFORM LMW);INTERACTION WITH CRISP3
      tissue: Serum.
    7. 7.
      "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B. , Van Damme J. , Martens L. , Vandekerckhove J. , Gevaert K.
      J. Proteome Res.5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-168
      strain: C57BL/6.
      tissue: Plasma.
    8. 8.
      "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K. , Kapp E.A. , Simpson R.J.
      J. Proteome Res.6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82; ASN-168; ASN-204 AND ASN-242
      strain: C57BL/6.
      tissue: Plasma.
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